The Bachelor, Daniil Dankovsky, is a player character for one of the first two available routes, and is generally considered the "default" character route. He is a bachelor of medicine from the Capitol who arrives to Town-on-Ghorkon after hearing of a man living there, Simon Kain, who is supposedly immortal. However, upon arriving, Simon and Daniil's interlocutor, Isidor Burakh, are announced dead with the latter being presumed the victim of a murder. With Daniil's reason for coming to the town now lost, Daniil investigates what might have happened and tries to navigate through the interpersonal relationships of the townspeople and the ruling families. Daniil learns that there is a plague growing in the town, and conspires to leave with two of his friends he had known in college after encouraging the town's government to prepare for the plague. However, the same people that Daniil spoke to end up putting the town on lockdown, and Daniil is unable to escape with his friends.

Pathologic follows the same setting and general plotline regardless of which of the three player characters (the Bachelor, the Haruspex, the Changeling) the player chooses, but their motivations and abilities differ. Overall, each character arrives to a small town in the Russian steppe called Town-on-Ghorkon. Significant members of the community are dying with talk of a serial killer or a mystical figure being the casue of these deaths, but it soon becomes evident that the deaths are caused due to a growing plague known as the Sand Pest, which has no known cure or vaccine. All player characters only have twelve days to save the town from annihilation from both the plague and the Powers That Be, the enigmatic embodiment of the law which seem to reside in the Capitol.





The Haruspex, Artemy Burakh, is a player character for one of the first two available routes and is the player character of Pathologic 2. He is a surgeon and son of Isidor Burakh, having been taught the cultural medical practices of his people, the Kin, who are indigenous to the Steppe. Artemy returns to Town-on-Ghorkon from the Capitol after receiving a letter from his father saying that he must speak with Artemy urgently. However, when Artemy arrives, he is immediately jumped at the trainyards because he is presumed to have murdered Isidor.
The following day, Artemy is given his inheritance, which includes all the duties of his father, the menkhu (a Kin who is given the right to open bodies) of Town-on-Ghorkon. In Pathologic 2, Artemy's responsibilities are introduced to him at his father's funeral, where the earth literally rejects Isidor's body until Artemy resolves his obligations.
The following day, Artemy is given his inheritance, which includes all the duties of his father, the menkhu (a Kin who is given the right to open bodies) of Town-on-Ghorkon. In Pathologic 2, Artemy's responsibilities are introduced to him at his father's funeral, where the earth literally rejects Isidor's body until Artemy resolves his obligations.



The Changeling, Clara, is an unlockable player character in Pathologic Classic and is only playable once both Daniil's and Artemy's routes have been completed. She is a mysterious young girl who awakes in the town at the bottom of a freshly dug grave. Her past and her motivations are unclear and made even more ambiguous by the fact that she can lie and contradict things in her dialogue choices. Unlike Daniil and Artemy, Clara has no medical means of addressing the plague, and relies instead on her ability to kill or heal with the laying on of hands.
Clara's route involves following the orders of her adopted family and trying to either help or hinder the efforts of Daniil or Artemy, all while she is being contacted by her twin sister, who might also be Clara herself.
Clara's route involves following the orders of her adopted family and trying to either help or hinder the efforts of Daniil or Artemy, all while she is being contacted by her twin sister, who might also be Clara herself.
